2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W015969R
    1-Aminopropan-2-ol (Standard) 78-96-6
    1-Aminopropan-2-ol (Standard) is the analytical standard of 1-Aminopropan-2-ol. This product is intended for research and analytical applications. 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
    1-Aminopropan-2-ol (Standard)
  • HY-W016009S
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium is deuterium labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium
  • HY-W016409R
    Ethyl 3,4-dihydroxybenzoate (Standard) 3943-89-3
    Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.
    Ethyl 3,4-dihydroxybenzoate (Standard)
  • HY-W016628R
    L-Gulono-1,4-lactone (Standard) 1128-23-0
    L-Gulono-1,4-lactone (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
    L-Gulono-1,4-lactone (Standard)
  • HY-W016647R
    For-Met-OH (Standard) 4289-98-9
    For-Met-OH (Standard) is the analytical standard of For-Met-OH. This product is intended for research and analytical applications. For-Met-OH is an endogenous metabolite.
    For-Met-OH (Standard)
  • HY-W016715R
    L-Cysteine hydrochloride hydrate (Standard) 7048-04-6
    L-Cysteine (hydrochloride hydrate) (Standard) is the analytical standard of L-Cysteine (hydrochloride hydrate). This product is intended for research and analytical applications. L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine hydrochloride hydrate (Standard)
  • HY-W016734R
    2-Amino-5-ureidopentanoic acid (Standard) 627-77-0
    2-Amino-5-ureidopentanoic acid (Standard) is the analytical standard of 2-Amino-5-ureidopentanoic acid. This product is intended for research and analytical applications. 2-Amino-5-ureidopentanoic acid is an endogenous metabolite.
    2-Amino-5-ureidopentanoic acid (Standard)
  • HY-W017006R
    1-Methyl-L-histidine (Standard) 332-80-9
    1-Methyl-L-histidine (Standard) is the analytical standard of 1-Methyl-L-histidine. This product is intended for research and analytical applications. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.
    1-Methyl-L-histidine (Standard)
  • HY-W017158R
    Melilotic acid (Standard) 495-78-3
    Vorapaxar (sulfate) (Standard) is the analytical standard of Vorapaxar (sulfate). This product is intended for research and analytical applications. Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
    Melilotic acid (Standard)
  • HY-W017163S
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9) 98%
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9) is the 13C and 15N labeled 7-Methylxanthine. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)
  • HY-W017370R
    Carveol (Standard) 99-48-9
    Carveol (Standard) is the analytical standard of Carveol. This product is intended for research and analytical applications. Carveol is an endogenous metabolite.
    Carveol (Standard)
  • HY-W017443R
    L-Asparagine monohydrate (Standard) 5794-13-8
    L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine monohydrate (Standard)
  • HY-W017462R
    Creatine monohydrate (Standard) 6020-87-7
    Creatine (monohydrate) (Standard) is the analytical standard of Creatine (monohydrate). This product is intended for research and analytical applications. Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
    Creatine monohydrate (Standard)
  • HY-W017540S
    Cyclocreatine-13C3 98%
    Cyclocreatine-13C3 is the 13C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer.
    Cyclocreatine-13C3
  • HY-W017613R
    (Ethoxymethyl)benzene (Standard) 539-30-0
    (Ethoxymethyl)benzene (Standard) is the analytical standard of (Ethoxymethyl)benzene. This product is intended for research and analytical applications. (Ethoxymethyl)benzene is an endogenous metabolite.
    (Ethoxymethyl)benzene (Standard)
  • HY-W018197R
    2-Phenylacetamide (Standard) 103-81-1
    2-Phenylacetamide (Standard) is the analytical standard of 2-Phenylacetamide. This product is intended for research and analytical applications. 2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active.
    2-Phenylacetamide (Standard)
  • HY-W018392R
    Mono-(2-ethylhexyl) phthalate (Standard) 4376-20-9
    Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD).
    Mono-(2-ethylhexyl) phthalate (Standard)
  • HY-W018512R
    7-Ketolithocholic acid (Standard) 4651-67-6
    7-Ketolithocholic acid (Standard) is the analytical standard of 7-Ketolithocholic acid. This product is intended for research and analytical applications. 7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.
    7-Ketolithocholic acid (Standard)
  • HY-W018653R
    Cyclohexaneacetic acid (Standard) 5292-21-7
    Naloxone (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias.
    Cyclohexaneacetic acid (Standard)
  • HY-W020215R
    Tricarballylic acid (Standard) 99-14-9
    Tricarballylic acid (Standard) is the analytical standard of Tricarballylic acid (HY-W020215). This product is intended for research and analytical applications. Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers.
    Tricarballylic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity